Медицинские книжки
Жанр:ГинЕкологическая эндокринология

It has become increasingly clear over the past several years that PCOS is a complex genetic disease resulting from the interaction of susceptibility genes and environmental factors The insight that prenatal агсешexposure to androgens can reproduce most of the features of the human syndrome in primates has led to a paradigm shift in concepts about the pathogenesis of the disorder The evidence for the fetal origins of PCOS will be reviewed in animal models as well as in human sагшжйtudies The novel mechanisms by which androgens may play a major role in the pathogenesis of the disorder will be presented Other emerging areas of PCOS will also be discussed, such as prepubertal precursors of PCOS and the association between PCOS, epilepsy, and antiseizure medications State-of-the-art treatment of the reproductive and metabolic consequences of the disorder will be reviewed Finally, the impact of the differing diagnostic criteria for PCOS will be reviewed .